沙眼动物模型：IV. 局部免疫抑制未能揭示隐性感染

An animal model of trachoma: IV. The failure of local immunosuppression to reveal inapparent infection.

作者信息

Taylor H R, Johnson S L, Schachter J, Prendergast R A

出版信息

Invest Ophthalmol Vis Sci. 1983 May;24(5):647-50.

Abstract

Repeated inoculation with live chlamydia trachomatis is necessary to develop a model of trachoma in monkeys. However, it is not possible to reisolate chlamydia from the monkey's eye after the first 1 or 2 months of weekly reinoculation. The effect of subconjunctival steroid injections in monkeys that had received weekly inoculations with live chlamydia is reported. Despite a profound suppression of local inflammation, steroid treatment did not produce a reactivation of identifiable chlamydial infection as determined by repeated chlamydial cultures and cytologic examinations.

摘要

为在猴子身上建立沙眼模型，有必要反复接种活的沙眼衣原体。然而，在每周重复接种的最初1或2个月后，无法从猴子眼中再次分离出衣原体。本文报告了对每周接种活沙眼衣原体的猴子进行结膜下注射类固醇的效果。尽管局部炎症受到了显著抑制，但通过反复的衣原体培养和细胞学检查确定，类固醇治疗并未使可识别的衣原体感染重新激活。