Abadir R, Ross G, Weinstein S H
Int J Radiat Oncol Biol Phys. 1983 Mar;9(3):305-9. doi: 10.1016/0360-3016(83)90288-2.
Sixty-three patients with cancer of the prostate T2 or T3 were evaluated. The protocol of treatment called for pelvic lymphadenectomy, 10,000 rad from I125 implant and 4000 rad in 20 fractions using a Cobalt60 machine. They were followed for 1 to 5 years with a plan to rebiopsy the prostate 1 to 2 years after therapy. Six of 59 evaluable patients (10%) showed progressive disease. Distinctive prognostic features in the failure group were younger age, larger prostate, more advanced stage, poorer differentiation, more possibility of positive pelvic lymph nodes, and if the nodes were positive, the involvement of more than two pelvic lymph nodes. On the other hand, the patients with controlled disease with or without positive prostatic biopsy on follow-up showed identical features regarding age, size of prostate, stage, differentiation, involvement of pelvic lymph nodes, and if the nodes were positive, only one or two nodes involved. Positive biopsy 1 to 2 years after radical irradiation in otherwise controlled disease is considered of no prognostic value.
对63例前列腺T2或T3期癌患者进行了评估。治疗方案要求进行盆腔淋巴结清扫术，通过I125植入物给予10000拉德照射，并使用钴60机器分20次给予4000拉德照射。对他们进行了1至5年的随访，并计划在治疗后1至2年对前列腺进行再次活检。59例可评估患者中有6例（10%）出现疾病进展。失败组的显著预后特征为年龄较轻、前列腺较大、分期较晚、分化较差、盆腔淋巴结阳性可能性较大，以及如果淋巴结阳性，则累及两个以上盆腔淋巴结。另一方面，随访时疾病得到控制（无论前列腺活检是否阳性）的患者在年龄、前列腺大小、分期、分化、盆腔淋巴结受累情况以及如果淋巴结阳性，则仅累及一两个淋巴结方面具有相同特征。在其他方面疾病得到控制的情况下，根治性放疗后1至2年活检阳性被认为没有预后价值。
