Farrell B M, Jefferies T M
J Chromatogr. 1983 Jan 14;272(1):111-28. doi: 10.1016/s0378-4347(00)86108-3.
Three pre-column derivatization reagents, namely o-phthalaldehyde, 4-chloro-7-nitro-benz-2,1,3-oxadiazole, sodium naphthaquinone-4-sulphonate and two ion-pair reagents, namely, naphthalene-2-sulphonate and sodium dodecylsulphate have been investigated for their suitability for the qualitative and quantitative analysis of urine and plasma samples containing amphetamines. The derivatization method employing sodium naphthaquinone-4-sulphonate was found to be selective and sufficiently sensitive for the routine determination of amphetamine and methylamphetamine in urine and plasma samples at the ng/ml level.
研究了三种柱前衍生试剂，即邻苯二甲醛、4-氯-7-硝基苯并-2,1,3-恶二唑、萘醌-4-磺酸钠，以及两种离子对试剂，即萘-2-磺酸盐和十二烷基磺酸钠，以考察它们对含苯丙胺的尿液和血浆样品进行定性和定量分析的适用性。结果发现，采用萘醌-4-磺酸钠的衍生化方法对尿液和血浆样品中苯丙胺和甲基苯丙胺的常规测定具有选择性，且在纳克/毫升水平上具有足够的灵敏度。
