实验性免疫性滑膜炎中关节内透明质酸注射与滑膜前列腺素
Intraarticular hyaluronic acid injection and synovial prostaglandins in experimental immune synovitis.
作者信息
Rosner I A, Boja B A, Malemud C J, Moskowitz R W, Goldberg V M
出版信息
J Rheumatol. 1983 Feb;10(1):71-8.
In vitro studies suggest that synovial fluid hyaluronic acid may have a role in reducing joint inflammation. The effect of intraarticular injection of sodium hyaluronate in a model of experimental immune synovitis was assessed. In addition, tissue prostaglandin content of synovia with and without immune synovitis was compared. Intraarticular hyaluronic acid administered at 2 doses was not effective in reducing the induced inflammation. With immune synovitis there was an increase in the total synovial prostaglandins. When related to total prostaglandins, prostacyclin was decreased, prostaglandin F2 alpha and thromboxane were increased and prostaglandin E2 was the same in synovitis as compared to controls.
体外研究表明，滑液透明质酸可能在减轻关节炎症方面发挥作用。评估了在实验性免疫性滑膜炎模型中关节内注射透明质酸钠的效果。此外，比较了有和没有免疫性滑膜炎的滑膜组织前列腺素含量。以两种剂量给予的关节内透明质酸在减轻诱导的炎症方面无效。在免疫性滑膜炎中，滑膜前列腺素总量增加。与总前列腺素相关时，免疫性滑膜炎中前列环素减少，前列腺素F2α和血栓素增加，前列腺素E2与对照组相同。
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