取代吡啶并嘧啶对黄嘌呤氧化酶的选择性抑制作用。
Selective inhibition of xanthine oxidase by substituted pyridopyrimidines.
作者信息
Kaur S, Raman K, Pandey B R, Barthwal J P, Kishor K, Kumar A, Bhargava K P, Ali B
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):103-13.
PMID:684270
Abstract
Six 2-methyl-3-substituted-pyrido-(2,3-d)-pyrimidine 4 (3H)-ones were synthesized and evaluated for their ability to inhibit xanthine oxidase and other purine catabolizing enzymes of rat liver. All compounds inhibited xanthine oxidase selectively when tested at a final concentration of 0.5 mM in vitro. Adenosine deaminase, guanosine deaminase and guanine deaminase were unaffected. The inhibition of xanthine oxidase was found to be competitive in nature.
摘要
合成了六种2-甲基-3-取代吡啶并[2,3-d]嘧啶-4（3H）-酮，并评估了它们抑制大鼠肝脏黄嘌呤氧化酶和其他嘌呤分解代谢酶的能力。在体外终浓度为0.5 mM进行测试时，所有化合物均选择性地抑制黄嘌呤氧化酶。腺苷脱氨酶、鸟苷脱氨酶和鸟嘌呤脱氨酶未受影响。发现黄嘌呤氧化酶的抑制作用本质上是竞争性的。
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