心得宁诱导的犬心脏β1肾上腺素能阻断作用的效能。
The efficacy of practolol-induced beta1 adrenergic blockade in the canine heart.
作者信息
Hoskins E J, Priola D V, Weiss G K
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):165-8.
PMID:684274
Abstract
The efficacy of adrenergic blockade with practolol was assessed by subjecting 6 adult mongrel dogs in a closed-chest procedure to bolus injections of isoproterenol (0.5 mcg/kg, i.v.) before and after practolol (2.0 mg/kg, i.v.). Following practolol both heart rate and pulse pressure responses were significantly reduced. It is suggested that significant beta1 receptor adrenergic blockade is achieved by practolol.
摘要
通过在开胸手术中对6只成年杂种犬静脉推注普萘洛尔（2.0mg/kg）前后静脉推注异丙肾上腺素（0.5mcg/kg），评估了普萘洛尔的肾上腺素能阻断效果。给予普萘洛尔后，心率和脉压反应均显著降低。提示普萘洛尔可实现显著的β1受体肾上腺素能阻断。
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