作为抗炎剂的取代氧代噻唑基乙酸
Substituted oxothiazolyl acetic acids as antiinflammatory agents.
作者信息
Raman K, Pandey B R, Barthwal J P, Bhargava K P, Parmar S S
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):177-80.
PMID:684277
Abstract
Eight 2-arylimino-3-[/3-(3,4-dimethoxyphenyl) ethy1]-4-oxothiazol-5-yl-acetic acids were synthesized, characterized, and evaluated for their antiinflammatory and antiproteolytic properties. The toxocity of the compounds was reflected by their approximate LD50 values.
摘要
合成了8种2-芳基亚氨基-3-[3-(3,4-二甲氧基苯基)乙基]-4-氧代噻唑-5-基乙酸，对其进行了表征，并评估了它们的抗炎和抗蛋白水解特性。这些化合物的毒性通过其近似的半数致死量（LD50）值反映出来。
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