Hara T, Nishikawa S, Miyazaki H, Ohguro Y
Jpn J Antibiot. 1983 Jan;36(1):174-6.
Micronomicin (MCR) is a new aminoglycoside antibiotic produced by Micromonospora sagamiensis var. nonreducans which was isolated from soil collected at Sagamihara by Nara et al. The purified antibiotic showed a close similarity to gentamicin C complex in physical and chemical properties. The antibacterial activity of MCR is broad-spectrum and almost equal to that of gentamicin C complex. MCR exhibits particularly high activity against Pseudomonas, Proteus, Klebsiella pneumoniae, Serratia, etc. and high activity against some Pseudomonas aeruginosa strains resistant to gentamicin C1a. A study on the irritation by repeated intravenous injection in dogs was carried out for safety evaluation (Doses: 4, 10, 25, 63 mg/kg and 100 mg/kg). Bleeding, edema, vasculitis and perivasculitis were observed at injection sites both in physiological saline-treated controls and MCR-treated groups. But irritation attributable to MCR was not observed at any dose.
小诺米星（MCR）是由相模小单孢菌非还原变种产生的一种新型氨基糖苷类抗生素，该菌株由奈良等人从相模原采集的土壤中分离得到。纯化后的抗生素在物理和化学性质上与庆大霉素C复合物极为相似。MCR的抗菌活性具有广谱性，几乎与庆大霉素C复合物相当。MCR对假单胞菌属、变形杆菌属、肺炎克雷伯菌、沙雷氏菌属等表现出特别高的活性，对一些耐庆大霉素C1a的铜绿假单胞菌菌株也具有高活性。为进行安全性评估，对犬重复静脉注射进行了刺激性研究（剂量：4、10、25、63mg/kg和100mg/kg）。在生理盐水处理的对照组和MCR处理组的注射部位均观察到出血、水肿、血管炎和血管周围炎。但在任何剂量下均未观察到由MCR引起的刺激性。
