Kaysen G A, Kropp J
Kidney Int. 1983 Mar;23(3):473-9. doi: 10.1038/ki.1983.44.
Surgical reduction of renal mass in the rat leads to proteinuria, hypertension, and progressive renal failure beyond that of the original physical destruction of renal mass. Both hypertension and proteinuria have been implicated in the process of progression of renal failure. The seven/eighths nephrectomized rats fed a diet supplemented with 4% tryptophan (UT) had a urinary albumin excretion rate of 0.055 +/- 0.056 mg/100 g body weight/hr compared to 0.02 +/- 0.029 mg/100 g body weight/hr in control rats, whereas the nephrectomized rats fed a regular diet (UR) excreted 1.12 +/- 0.730 mg/100 g body weight/hr (P less than 0.001). Hypertension was also prevented in the UT group but not in the UR group. Once hypertension and proteinuria were established during maintenance on a regular diet, they were not reversed by subsequent dietary tryptophan supplementation. If dietary tryptophan supplementation is continued, however, the progressive histopathology that develops after seven-eighths nephrectomy is not prevented despite avoidance of proteinuria and hypertension.
大鼠肾脏肿块的手术切除会导致蛋白尿、高血压以及超出肾脏肿块原有物理破坏程度的进行性肾衰竭。高血压和蛋白尿都与肾衰竭的进展过程有关。喂食添加4%色氨酸饮食的七分之八肾切除大鼠（UT）的尿白蛋白排泄率为0.055±0.056毫克/100克体重/小时，而对照大鼠为0.02±0.029毫克/100克体重/小时，而喂食常规饮食的肾切除大鼠（UR）排泄率为1.12±0.730毫克/100克体重/小时（P<0.001）。UT组的高血压也得到了预防，但UR组没有。一旦在常规饮食维持期间出现高血压和蛋白尿，随后补充饮食色氨酸并不能使其逆转。然而，如果继续补充饮食色氨酸，尽管避免了蛋白尿和高血压，但七分之八肾切除术后发展的进行性组织病理学仍无法预防。
