Srám R J, Dobiás L, Pastorková A, Rössner P, Janca L
Mutat Res. 1983 May;120(2-3):181-6. doi: 10.1016/0165-7992(83)90161-6.
The possible anti-mutagenic potential of prophylactically administered ascorbic acid (AA) preparations was studied in a group of 35 coal-tar workers occupationally exposed to PAH and benzene. The effectiveness of AA prophylaxis was assessed by differences in the frequency of chromosome aberrations in peripheral blood lymphocytes of the exposed workers examined before and after a 3-month treatment with AA at the daily doses of 1.0 g for 5 days a week. In the exposed group the cytogenetic analysis of peripheral blood lymphocytes revealed a significant drop in the frequency of aberrant cells (AB.C.) from the initial 5.07% AB.C. (0.0657 B/C, breaks per cell) to 1.77% AB.C. (0.0197 B/C). In a group of matching controls the frequency of AB.C. was 1.50% (0.0170 B/C) and 1.45% (0.0180 B/C), respectively. The study showed that the risk of genetic injury assessed by the frequency of chromosome aberrations in peripheral blood lymphocytes was substantially reduced after AA prophylaxis.
在一组35名职业性接触多环芳烃（PAH）和苯的煤焦油工人中，研究了预防性给予抗坏血酸（AA）制剂可能具有的抗诱变潜力。通过对暴露工人外周血淋巴细胞染色体畸变频率的差异来评估AA预防的效果，这些工人在每周5天、每天剂量为1.0克的情况下接受了3个月的AA治疗，分别在治疗前后进行检查。在暴露组中，外周血淋巴细胞的细胞遗传学分析显示，异常细胞（AB.C.）的频率从最初的5.07% AB.C.（0.0657 B/C，每细胞断裂数）显著下降至1.77% AB.C.（0.0197 B/C）。在一组匹配的对照组中，AB.C.的频率分别为1.50%（0.0170 B/C）和1.45%（0.0180 B/C）。该研究表明，在进行AA预防后，通过外周血淋巴细胞染色体畸变频率评估的遗传损伤风险大幅降低。
