Khalil A M
Department of Biological Sciences, Yarmouk University, Irbid, Jordan.
Arch Environ Contam Toxicol. 1995 Feb;28(2):236-9. doi: 10.1007/BF00217622.
To evaluate the possible cytogenetic consequences of exposure of human populations to petrochemicals, the frequency of chromosomal aberrations was studied in blood lymphocytes obtained from 233 persons working at different locations in a large oil refinery (184 exposed and 49 worksite controls) and from 47 individuals who served as community controls. Chromosomal aberrations occurred with frequencies (mean +/- SEM) between 0.023 +/- 0.013 and 0.037 +/- 0.011 breaks per cell (1.56 +/- 0.87% to 2.66 +/- 0.54% aberrant cells) in the exposed groups. These values, with the exception of those observed in two workshops (crude oil unloading as well as petroleum tanker washing and lubrication), were significant compared to the presumably spontaneous (control) levels (0.015 +/- 0.004 to 0.021 +/- 0.007 breaks per cell and 1.17 +/- 0.29% to 1.46 +/- 0.40% aberrant cells). Cigarette-smoking was not associated with increased chromosomal aberrations in the exposed and in the control groups.
为评估人群接触石化产品可能产生的细胞遗传学后果，对从一家大型炼油厂不同工作地点的233名工人（184名暴露者和49名工作场所对照者）以及47名作为社区对照的个体采集的血液淋巴细胞中的染色体畸变频率进行了研究。在暴露组中，染色体畸变频率（平均值±标准误）为每细胞0.023±0.013至0.037±0.011次断裂（异常细胞为1.56±0.87%至2.66±0.54%）。与推测的自发（对照）水平（每细胞0.015±0.004至0.021±0.007次断裂，异常细胞为1.17±0.29%至1.46±0.40%）相比，除在两个车间（原油卸载以及油轮清洗和润滑）观察到的值外，这些值均具有显著性。在暴露组和对照组中，吸烟与染色体畸变增加无关。
