Tison P, Kubisz P, Cernácek P, Dzúrik R
Nephron. 1983;33(4):253-6. doi: 10.1159/000182963.
The inhibition of glycolysis by an inhibitor of glucose utilization isolated from urine of the uremic subjects reflects in: (1) decreased platelet aggregation induced by adenosine diphosphate, adrenaline, or collagen, respectively; (2) decreased platelet factor 4 release induced by the same inductors; (3) decreased availability of platelet factor 3, and (4) inhibition of retraction of reptilase clot. It is concluded that the inhibition of glycolysis by 'inhibitor of glucose utilization' contributes to the functional changes of platelets and thus to the alteration of hemostasis in uremic patients.
（1）分别由二磷酸腺苷、肾上腺素或胶原诱导的血小板聚集减少；（2）相同诱导剂诱导的血小板因子4释放减少；（3）血小板因子3可用性降低；（4）抑制蛇毒凝血酶凝块的回缩。得出的结论是，“葡萄糖利用抑制剂”对糖酵解的抑制作用导致血小板功能改变，进而导致尿毒症患者止血功能改变。
