Tomita T, McLone D G
Neurosurgery. 1983 Mar;12(3):265-7. doi: 10.1227/00006123-198303000-00002.
Five children with cerebellar medulloblastoma underwent cytological study for neoplastic cells in the cerebrospinal fluid (CSF) from the lateral ventricle and cisterna magna and biopsy of the arachnoid of the cisterna magna before the manipulation of a medulloblastoma. In all cases, seeding of neoplastic cells was present in the CSF or arachnoid of the cisterna magna, whereas the ventricular fluid was negative for neoplastic cells. This study suggests that medulloblastoma seeds spontaneously into the subarachnoid space, thus supporting the need for postoperative whole neuraxis radiation.
5例小脑髓母细胞瘤患儿在对髓母细胞瘤进行手术操作前，对侧脑室和枕大池脑脊液（CSF）中的肿瘤细胞进行了细胞学研究，并对枕大池蛛网膜进行了活检。在所有病例中，枕大池脑脊液或蛛网膜中均存在肿瘤细胞种植，而脑室液中肿瘤细胞呈阴性。本研究表明，髓母细胞瘤可自发种植至蛛网膜下腔，因此支持术后全脑脊髓放疗的必要性。
