Chanen W, Rome R M
Obstet Gynecol. 1983 Jun;61(6):673-9.
The present report assesses 15 years' experience with electrocoagulation diathermy in the treatment of cervical intraepithelial neoplasia (CIN). Selection is based on the ability to visualize the boundaries of the lesion colposcopically. Visualization, together with cytology and target biopsy, should exclude invasive carcinoma. Histologically confirmed CIN of varying severity (almost two thirds were CIN III) was treated by diathermy in 1864 patients. The size of the lesion varied, and at times the lesion extended into the endocervical canal. Cervical intraepithelial neoplasia was eradicated in 97.3% of patients by a single diathermy treatment. Ninety-three percent of all patients under the age of 30 with CIN were treated by this method. Progression to invasive carcinoma after diathermy has not been demonstrated. A single treatment with electrocoagulation diathermy has proved consistently to be the most effective superficial ablative method for primary eradication of CIN whether deep, extensive, or of major severity.
本报告评估了电凝透热疗法治疗宫颈上皮内瘤变（CIN）15年的经验。选择该疗法的依据是能够在阴道镜下清晰显示病变边界。阴道镜检查、细胞学检查及靶向活检相结合应能排除浸润癌。1864例经组织学确诊为不同严重程度CIN（近三分之二为CIN III）的患者接受了透热疗法治疗。病变大小各异，有时病变会延伸至宫颈管内。单次透热疗法使97.3%的患者宫颈上皮内瘤变得以根除。所有30岁以下CIN患者中，93%采用了该方法治疗。尚未证实透热疗法后会进展为浸润癌。事实证明，无论CIN病变是深部、广泛还是严重，单次电凝透热疗法始终是原发性根除CIN最有效的浅表消融方法。
