[贫血动物造血干细胞对放线菌素D的敏感性]
[Sensitivity of the hematopoietic stem cells of anemic animals to actinomycin D].
作者信息
Domaratskaia E I, Polikarpova S I
出版信息
Ontogenez. 1983 Mar-Apr;14(2):162-5.
PMID:6843952
Abstract
It was shown on the model of anemic animals by the method of spleen colonies that non-proliferating CFU-S were resistant against the cytotoxic effect of actinomycin D in concentrations 0.04 to 0.4 micrograms/ml. The entry of CFU-S in proliferation was accompanied by a sharp increase of the sensitivity to the antibiotic in a dose blocking DNA-dependent rRNA synthesis.
摘要
通过脾集落法在贫血动物模型上显示，非增殖性CFU-S对浓度为0.04至0.4微克/毫升的放线菌素D的细胞毒性作用具有抗性。CFU-S进入增殖状态伴随着对该抗生素敏感性的急剧增加，这种剂量会阻断依赖DNA的rRNA合成。
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