Levy J V
Proc Soc Exp Biol Med. 1983 Mar;172(3):393-5. doi: 10.3181/00379727-172-3-rc1.
Experiments were done to test the hypothesis that aggregation of human platelets induced by platelet activating factor (PAF) may be mediated by calmodulin-dependent processes. W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide], a potent calmodulin antagonist, caused dose-dependent inhibition of PAF induced aggregation of human platelets in vitro. The ED50 for W-7 was 51.5 +/- 9.5 microM (mean +/- SEM). This concentration is known to be platelet calmodulin-specific. These data are consistent with the hypothesis.
血小板活化因子（PAF）诱导的人血小板聚集可能由钙调蛋白依赖性过程介导。W-7 [N-(6-氨基己基)-5-氯-1-萘磺酰胺]，一种有效的钙调蛋白拮抗剂，在体外对PAF诱导的人血小板聚集产生剂量依赖性抑制。W-7的半数有效剂量（ED50）为51.5 +/- 9.5微摩尔（平均值 +/- 标准误）。已知该浓度具有血小板钙调蛋白特异性。这些数据与该假说相符。
