Gobé G C, Axelsen R A
Res Commun Chem Pathol Pharmacol. 1983 Jan;39(1):11-28.
An investigation was carried out to determine whether or not the administration of indomethacin to Li-treated rats would raise PLi2, and whether or not there would be any change in the type or severity of Li-induced renal functional abnormalities. It was found that indomethacin increased PLi, apparently by decreasing CLi. Umax, already reduced by Li, was further impaired by the additional administration of indomethacin. The Li-induced impairment of TcH2O was not worsened by added indomethacin, but a wide variance of the data might have masked any effect. Significant inverse correlations were found between Umax and PLi and between maximum TcH2O and PLi, suggesting that the indomethacin-induced impairment in renal concentrating capacity is attributable to the increased PLi.
开展了一项研究，以确定给锂处理的大鼠施用吲哚美辛是否会提高锂的血浆水平（PLi），以及锂诱导的肾功能异常的类型或严重程度是否会有任何变化。结果发现，吲哚美辛增加了PLi，显然是通过降低锂的清除率（CLi）实现的。已经因锂而降低的最大尿流率（Umax），因额外施用吲哚美辛而进一步受损。锂诱导的水清除率（TcH2O）损害并未因添加吲哚美辛而恶化，但数据的广泛差异可能掩盖了任何影响。在Umax与PLi之间以及最大TcH2O与PLi之间发现了显著的负相关，这表明吲哚美辛诱导的肾浓缩能力损害归因于PLi的增加。
