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Thiazides III. Evidence of dose proportionality of hydrochlorothiazide 25, 50 and 100 mg tablets.

作者信息

Shah V P, Lee J J, Prasad V K, Hunt J P, Cabana B E

出版信息

Res Commun Chem Pathol Pharmacol. 1983 Jan;39(1):39-48.

PMID:6844739
Abstract

A pilot bioavailability study was carried out where two subjects each were administered a dose of 25, 50 or 100 mg of commercially available hydrochlorothiazide (HCT) tablets. Plasma and urine samples were collected and analyzed by HPLC. A maximum plasma concentration of 50-285 ng/ml was reached in 1-2 hours, and plasma levels declined very rapidly with a half life of about 2-4 hours during first 12 hours period. The AUC was calculated using the trapezodial rule. A linear correlation was seen between the dose administered and amount of drug excreted.

摘要

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