Ballard J
South Med J. 1978 Aug;71(8):966-7.
A case of bilateral testicular tumors thought secondary to hyperplastic adrenal rest tissue in an adult with the adrenogenital syndrome is presented. The appropriate endocrinologic diagnosis of 21-hydroxylase deficiency was made by extensive hormonal assay of serum and urine. Pathologic investigation suggested Leydig cell hyperplasia or tumor, but clinical and laboratory response to steroid therapy indicated elaboration of androgens from adrenal or adrenal rest sources. We believe initial medical therapy is justified in these particular cases.
本文报告一例成年肾上腺生殖综合征患者双侧睾丸肿瘤，考虑继发于增生的肾上腺残余组织。通过对血清和尿液进行广泛的激素检测，做出了21-羟化酶缺乏的恰当内分泌诊断。病理检查提示为Leydig细胞增生或肿瘤，但对类固醇治疗的临床和实验室反应表明雄激素是由肾上腺或肾上腺残余组织产生的。我们认为在这些特殊病例中，初始药物治疗是合理的。
