Combined use of lithium and diuretics.

Three cases demonstrating the effects of the combined use of lithium carbonate and a diuretic are reported. In each case, the serum lithium level rose, or the daily dose was decreased, or both. No clinical problems were noted because of careful monitoring and patient education. The renal excretion of lithium is reviewed. It is concluded that lithium and diuretics is a safe drug combination, if it is necessary to give both drugs.