Romana L K, Singh S, Ahuja S P
Z Ernahrungswiss. 1983 Jan;22(1):59-64. doi: 10.1007/BF02020786.
30 rats were divided into 3 groups to study the effects of erucic-acid-rich mustard oil (MO) and MO plus fish oil and carnitine (MOFOC) diet as compared to groundnut oil (GNO) diet on the collagen biosynthesis in various tissues. Changes in collagen content and monoamine oxidase (MAO) of hearts, aorta, skeletal muscles, lungs and skin were determined after 24, 60 and 80 days of feeding, respectively. Incorporation of U-14C-proline into collagen of these tissues was also studied. MO diets increased the incorporation of U-14C-proline into total and acid-insoluble collagen in heart, skeletal muscles and lungs but this increase was of lower magnitude in heart and skeletal muscles as compared with MOFOC diet. Total and acid-insoluble collagen contents in all these tissues, except skin, were increased by MO diet and MOFOC diet retarded this increase. Similar trends were observed in the activities of MAO. The results suggest that the MO diet increases both the biosynthesis and maturation of collagen and MOFOC diet retards this trend. The response of various tissues being variable in this respect.
将30只大鼠分为3组，以研究富含芥酸的芥子油（MO）、MO加鱼油和肉碱（MOFOC）饮食与花生油（GNO）饮食相比，对各种组织中胶原蛋白生物合成的影响。分别在喂食24、60和80天后，测定心脏、主动脉、骨骼肌、肺和皮肤的胶原蛋白含量和单胺氧化酶（MAO）的变化。还研究了U-14C-脯氨酸掺入这些组织胶原蛋白中的情况。MO饮食增加了U-14C-脯氨酸掺入心脏、骨骼肌和肺中总胶原蛋白和酸不溶性胶原蛋白的量，但与MOFOC饮食相比，心脏和骨骼肌中的这种增加幅度较小。MO饮食和MOFOC饮食增加了所有这些组织（皮肤除外）中总胶原蛋白和酸不溶性胶原蛋白的含量，而MOFOC饮食减缓了这种增加。在MAO的活性方面也观察到了类似的趋势。结果表明，MO饮食增加了胶原蛋白的生物合成和成熟，而MOFOC饮食减缓了这一趋势。在这方面，各种组织的反应各不相同。
