Garland H O, Balment R J, Brimble M J
Acta Endocrinol (Copenh). 1983 Apr;102(4):517-20. doi: 10.1530/acta.0.1020517.
Direct measurements of proximal tubular fluid reabsorption have been employed to examine the possible renal site of action of oxytocin. In whole kidney studies the natriuresis and chloriuresis, which occurred during the period of oxytocin infusion, did not coincide with the associated diuresis. The latter reached a peak 10-20 min after hormone administration has ceased. The separation in the saliuretic and diuretic responses underlines the apparent independence of these actions of oxytocin on the renal handling of water and electrolytes. The disturbances in renal function were not related to any change in glomerular filtration rate (gfr) and an examination of single nephron function failed to detect any significant effect of oxytocin on proximal tubular reabsorption. The renal actions of oxytocin would therefore appear to emanate from altered tubular rather than glomerular function, though the present study provides no support for a proximal site of action.
已采用对近端肾小管液重吸收的直接测量来研究催产素可能的肾脏作用部位。在全肾研究中，催产素输注期间出现的利钠和利氯作用与相关的利尿作用并不一致。后者在激素给药停止后10 - 20分钟达到峰值。利盐和利尿反应的分离突出了催产素对肾脏水和电解质处理的这些作用明显的独立性。肾功能紊乱与肾小球滤过率（GFR）的任何变化均无关，对单个肾单位功能的检查未能检测到催产素对近端肾小管重吸收有任何显著影响。因此，催产素的肾脏作用似乎源于肾小管功能改变而非肾小球功能改变，尽管本研究不支持近端作用部位。
