Swierstra B A
Acta Orthop Scand. 1983 Apr;54(2):317-21. doi: 10.3109/17453678308996577.
The Hulth procedure was used to induce osteoarthrosis in a knee-joint in 36 rabbits, whereupon changes in chondral and synovial morphology and lysosomal enzyme activities were studied over a period of 3 months. A significant increase in enzyme activities was observed, which was more pronounced and seemed to occur earlier in the synovial membrane than in the cartilage. The synovial morphological changes were conspicuous in an early stage of the disease process and also seemed to precede the changes in chondral morphology. The results of this study suggest an important role of the synovial membrane in the pathogenesis of osteoarthrosis.
采用胡尔特手术在36只兔子的膝关节诱导骨关节炎，随后在3个月的时间里研究软骨和滑膜形态以及溶酶体酶活性的变化。观察到酶活性显著增加，滑膜中的增加更为明显且似乎比软骨中更早出现。滑膜形态变化在疾病过程的早期很明显，而且似乎也先于软骨形态变化。本研究结果表明滑膜在骨关节炎发病机制中起重要作用。
