Keiding S, Mengel H, Lund J
Acta Pharmacol Toxicol (Copenh). 1983 Mar;52(3):234-7. doi: 10.1111/j.1600-0773.1983.tb01092.x.
Hepatic elimination of femoxetine was studied in six anaesthetized pigs during intravenous administration. Femoxetine was given into a jugular vein as a constant infusion of 0.4-7.2 mg/min. in five pigs and as a bolus injection of 383 mg in one pig. The hepatic extraction was high (92-98%) corresponding to earlier findings of 91-99% when femoxetine was infused into the portal vein in pig or given orally to man. The urinary excretion was low, less than 5% of the dose, and the estimated extrahepatic metabolism was not significantly different from zero.
在六只麻醉猪静脉给药期间研究了非莫西汀的肝脏消除情况。五只猪以0.4 - 7.2毫克/分钟的恒定速率通过颈静脉输注非莫西汀，一只猪静脉推注383毫克。肝脏提取率很高（92 - 98%），这与之前的研究结果相符，即在猪中通过门静脉输注非莫西汀或给人口服时，提取率为91 - 99%。尿排泄量很低，不到给药剂量的5%，并且估计的肝外代谢与零无显著差异。
