Larsson G, Alm P, Gullberg B, Grundsell H
Am J Obstet Gynecol. 1983 May 15;146(2):145-53. doi: 10.1016/0002-9378(83)91043-8.
Three hundred forty-three cases of early invasive carcinoma of the uterine cervix were analyzed. Depth of infiltration and lateral extension of the tumors varied between 0.2 and 9.0 mm and 0.4 and 17.2 mm and were found to be of no prognostic importance. A multivariate statistical analysis revealed several risk factors: an epithelialized portio at diagnosis, suspected or evident tumor invasion in capillary-like spaces, absence of tumor-free margins at conization, and treatment with conization or simple hysterectomy, especially in the presence of the above-mentioned factors. Tumors of a large cell keratinizing type were prognostically favorable. Confluent growth was not associated with increased risk of recurrence or death from recurrence. Cervical biopsies proved to be inadequate as diagnostic material. Recurrences were almost always local and developed late. In absence of risk factors conization is sufficient treatment. In the presence of risk factors treatment should be the same as that performed for frankly invasive Stage IB carcinomas.
对343例宫颈早期浸润癌病例进行了分析。肿瘤的浸润深度和侧向扩散范围分别在0.2至9.0毫米和0.4至17.2毫米之间，发现其对预后无重要意义。多变量统计分析揭示了几个风险因素：诊断时的上皮化生区、疑似或明显的肿瘤在毛细血管样间隙中的浸润、锥切时无肿瘤切缘以及采用锥切或单纯子宫切除术治疗，特别是在存在上述因素的情况下。大细胞角化型肿瘤预后良好。融合性生长与复发风险增加或复发死亡无关。宫颈活检被证明作为诊断材料不足。复发几乎总是局部的且发生较晚。在没有风险因素的情况下，锥切是足够的治疗方法。在存在风险因素的情况下，治疗应与对明显浸润性IB期癌所采用的治疗方法相同。
