Palestine A G, Meyers S M, Fauci A S, Gallin J I
Am J Ophthalmol. 1983 May;95(5):598-604. doi: 10.1016/0002-9394(83)90377-x.
Of 32 patients (19 females and 13 males, ranging in age from 2 to 44 years), nine had ocular problems related to neutrophil dysfunction. Four patients had blepharokeratoconjunctivitis and pannus formation. In one of these, severe visual loss secondary to corneal thinning and scarring occurred. Five patients had inactive chorioretinal scars without visual loss. Although some of the other 23 patients had minor ocular abnormalities, we could not demonstrate that they were related to the neutrophil dysfunction. However, none of the control subjects (20 patients with systemic lupus erythematosus and 20 randomly selected eye clinic patients) had lesions resembling those of the patients with neutrophil dysfunction. Fisher's exact test (one-tailed) gave the following values: P less than .03 for keratitis; P less than .01 for chorioretinal scars; and P less than .001 for keratitis and chorioretinal scars. Abnormal neutrophil function probably interferes with the control of normal eyelid flora and predisposes the eye to the development of marginal keratitis. Eyelid hygiene and topical administration of antibiotics and corticosteroids during inflammatory episodes may prevent the progression of corneal vascularization. The chorioretinal scars do not appear to be progressive.
在32例患者（19例女性，13例男性，年龄范围为2至44岁）中，9例有与中性粒细胞功能障碍相关的眼部问题。4例患者患有睑角膜结膜炎和血管翳形成。其中1例因角膜变薄和瘢痕形成导致严重视力丧失。5例患者有静止性脉络膜视网膜瘢痕但无视力丧失。虽然其他23例患者中有一些有轻微眼部异常，但我们无法证明它们与中性粒细胞功能障碍有关。然而，对照组受试者（20例系统性红斑狼疮患者和20例随机选择的眼科门诊患者）均无类似中性粒细胞功能障碍患者的病变。Fisher精确检验（单尾）得出以下值：角膜炎P值小于0.03；脉络膜视网膜瘢痕P值小于0.01；角膜炎和脉络膜视网膜瘢痕P值小于0.001。中性粒细胞功能异常可能会干扰正常眼睑菌群的控制，使眼睛易患边缘性角膜炎。在炎症发作期间进行眼睑卫生护理以及局部使用抗生素和皮质类固醇可能会防止角膜血管化的进展。脉络膜视网膜瘢痕似乎不会进展。
