Progress report on experimental use of CYBEST model 2 for practical gynecologic mass screening. Alterations of the specimen rejection threshold and specimen preparation.

In order to maintain an acceptable performance of CYBEST model 2 in the field of gynecologic mass screening, the algorithm of rejection for the CYBEST assessment of inadequately oligocellular samples was reviewed, and the mean number of detected cells per square millimeter for passing rejection was raised from two cells to four. The results of field tests obtained after the modification showed a false-positive rate of 28.3% for 9,010 samples as compared with 41.8% for 10,549 samples before the modification while the rejection rate showed a moderate yet acceptable increase after the modification from 4.7% to 7.0%. Some modifications of the specimen preparation routine were also introduced to improve the performance of the system.