溴莫普明和甲硫普明单独及与磺胺类药物联合对厌氧菌的活性。
Activity of brodimoprim and metioprim alone and in combination with sulfonamides against anaerobic bacteria.
作者信息
Wüst J, Schwarzenbach J
出版信息
Antimicrob Agents Chemother. 1983 Mar;23(3):490-2. doi: 10.1128/AAC.23.3.490.
Abstract
The activities of the 2,4-diamino-5-benzylpyrimidines brodimoprim and metioprim against anaerobic bacteria were tested alone and in combination with sulfonamides. Alone they were two to four times more active than trimethoprim, but in combination with sulfonamides, their activity was slightly lower than that of trimethoprim plus sulfamethoxazole.
摘要
对2,4-二氨基-5-苄基嘧啶类药物溴莫普明和甲氨普明针对厌氧菌的活性进行了单独测试，以及与磺胺类药物联合使用的测试。单独使用时，它们的活性比甲氧苄啶高两到四倍，但与磺胺类药物联合使用时，其活性略低于甲氧苄啶加磺胺甲恶唑。
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