Iakovleva N I
Arkh Patol. 1983;45(2):13-7.
Adenomas of the colon and rectum from 606 patients were examined among which 62.5% were tubular, 28.3% tubularvillous, 9.2% villous forms (according to the WHO classification). In 7 patients carcinoma in situ was found in the area of adenomas, in 10 patients "focal carcinoma" and in 55 patients adenocarcinoma with invasion into the submucous layer of the intestine wall. Three patients had primary multiple carcinoma in adenomatosis of the colon and rectum. The development of cancer was observed predominantly in adenomas with signs of epithelial dysplasia of the II--III degree. Carcinoma in situ and "focal carcinoma" are stages in the establishment of the tumor growth.