Lodder J, de Weerd A W, Koetsier J C, van der Lugt P J
Arch Neurol. 1983 May;40(5):320-2. doi: 10.1001/archneur.1983.04050050088015.
In two cases of acute cerebral multiple sclerosis, computed tomographic (CT) scans with contrast disclosed several enhanced foci, mainly situated in the periventricular white matter and, in one patient, in the cerebellum. Administration of dexamethasone sodium phosphate in one patient and prednisone with cyclophosphamide in the other was followed by considerable clinical improvement. Successive CT scans with contrast enhancement showed a close correlation between improvement of symptoms and the subsidence of contrast-enhanced foci during treatment. Perhaps clinical improvement reflected restoration of the impaired blood-brain barrier.
在两例急性脑多发性硬化症患者中，增强计算机断层扫描（CT）显示出多个强化灶，主要位于脑室周围白质，其中一例患者的小脑也有强化灶。一例患者使用地塞米松磷酸钠，另一例患者使用泼尼松联合环磷酰胺治疗后，临床症状有显著改善。连续的增强CT扫描显示，治疗期间症状改善与强化灶消退之间存在密切相关性。临床症状的改善可能反映了受损血脑屏障的恢复。
