Selbst R G, Selhorst J B, Harbison J W, Myer E C
Arch Neurol. 1983 Jun;40(6):347-50. doi: 10.1001/archneur.1983.04050060047007.
Severe loss of vision and bilateral optic disc edema occurred in a 10-year-old girl 38 days after the rash of varicella first appeared and subsequent encephalitis developed. Recovery of visual function was nearly complete, but optic atrophy persisted. Parainfectious optic neuritis following other viral infections, with the exception of herpes zoster, has a similar clinical profile: delayed onset, severe visual loss, optic disc edema, bilaterality, good recovery, and residual optic atrophy. Conduction delays in our patient's patterned visual evoked potentials implicated demyelination within the optic nerves. The often favorable recovery, frequency of delayed onset, and bilateral involvement of the optic nerves support an autoimmune process in the pathogenesis of parainfectious optic neuritis.
一名10岁女孩在水痘皮疹首次出现并继发脑炎38天后，出现严重视力丧失和双侧视盘水肿。视觉功能几乎完全恢复，但视神经萎缩持续存在。除带状疱疹外，其他病毒感染后的感染后性视神经炎具有相似的临床特征：发病延迟、严重视力丧失、视盘水肿、双侧性、恢复良好以及残留视神经萎缩。我们患者的图形视觉诱发电位传导延迟提示视神经存在脱髓鞘病变。感染后性视神经炎发病机制中常出现的良好恢复、延迟发病频率以及视神经双侧受累支持自身免疫过程。
