在分离的神经末梢中依赖胞苷一磷酸的磷脂酰肌醇：肌醇交换活性
CMP-dependent phosphatidylinositol:myo-inositol exchange activity in isolated nerve-endings.
作者信息
Berry G, Yandrasitz J R, Segal S
出版信息
Biochem Biophys Res Commun. 1983 May 16;112(3):817-21. doi: 10.1016/0006-291x(83)91690-x.
PMID:6847682
Abstract
Greatly enhanced manganese-dependent phosphatidylinositol:myo-inositol exchange activity was observed when isolated, intact nerve-endings were incubated with the nucleotide, CMP, suggesting that the enzyme, CDP-diglyceride:inositol phosphatidyl transferase, catalyzes this exchange. CMP, at 10 microM, produced as much myo-[2-3H] inositol incorporation into phosphatidylinositol as did 1 mM. This CMP-stimulated exchange activity may reside on the plasma membrane.
摘要
当分离出的完整神经末梢与核苷酸CMP一起孵育时，观察到锰依赖性磷脂酰肌醇：肌醇交换活性大大增强，这表明CDP - 甘油二酯：肌醇磷脂转移酶催化了这种交换。10 microM的CMP产生的肌醇[2 - 3H]掺入磷脂酰肌醇的量与1 mM的相同。这种CMP刺激的交换活性可能存在于质膜上。
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