Hirtz D G, Nelson K B, Ellenberg J H
J Pediatr. 1983 Jan;102(1):14-8. doi: 10.1016/s0022-3476(83)80278-9.
In 1.4% of children who experienced a seizure during the first seven years of life, the seizure followed within two weeks of an immunization procedure. We report 40 postimmunization seizures in 39 children enrolled in the Collaborative Perinatal Project. Ten seizures followed diphtheria-pertussis-tetanus (DPT) immunization, and 10 followed measles immunization. All but one of the seizures were associated with fever, often high. Thirty-seven seizures lasted less than 30 minutes. More than half of the children had a personal or immediate-family history of febrile seizures. One of the children had a right focal seizure lasting six hours after DPT immunization and had a significant speech deficit on long-term follow-up. No child developed epilepsy, and results in all children with brief seizures were normal on neurologic and cognitive examination at 7 years of age. Both in clinical presentation and generally benign outcome, these immunization-related seizures closely resemble febrile seizures, which are common in early childhood.
在1.4%的7岁前发生过癫痫发作的儿童中，癫痫发作发生在免疫接种程序后的两周内。我们报告了参与围产期协作项目的39名儿童中有40例接种疫苗后癫痫发作。10例癫痫发作发生在白喉-百日咳-破伤风（DPT）疫苗接种后，10例发生在麻疹疫苗接种后。除1例癫痫发作外，其余均伴有发热，且常常是高热。37例癫痫发作持续时间不到30分钟。超过半数的儿童有个人或直系家族热性惊厥病史。其中1名儿童在接种DPT疫苗后出现右侧局灶性癫痫发作，持续6小时，长期随访时有明显的语言缺陷。没有儿童发展为癫痫，所有癫痫发作短暂的儿童在7岁时的神经和认知检查结果均正常。无论是临床表现还是总体良性结局，这些与免疫接种相关的癫痫发作与幼儿期常见的热性惊厥极为相似。
