Brown A J, Clark S A, Lever A F
Am J Physiol. 1983 Jan;244(1):F84-8. doi: 10.1152/ajprenal.1983.244.1.F84.
Our objectives were to determine whether saralasin, like angiotensin II, raises blood pressure gradually when given by constant infusion and whether either agent alters the diurnal variation of arterial pressure. Eight female Wistar rats were infused intravenously with 5% dextrose for 2 days, then with saralasin at 10 micrograms . kg-1 . min-1 for 4 days, and finally with dextrose for 2 days. Six other rats were infused with angiotensin II (20 ng . kg-1 . min-1) instead of saralasin. Mean arterial pressure (MAP) was recorded continuously. Saralasin and angiotensin II gradually raised MAP in all rats, by 22.0 mmHg on the 4th day of saralasin and by 41.7 mmHg on the 4th day of angiotensin II. Both agents also increased the diurnal variation of blood pressure, MAP increasing 8.3-20.6 mmHg during the night and falling 6.7-19.1 mmHg during the day. Variability of arterial pressure was also increased by saralasin and in an earlier experiment by angiotensin II. We conclude that saralasin has a slow pressor action similar to that of angiotensin II but distinct in its timing both from the rapid agonist action of saralasin and from the acute vasoconstrictor action of angiotensin II. These effects of saralasin may compromise interpretation of experiments in which the drug is given by prolonged infusion to assess the role of angiotensin II.
我们的目标是确定沙拉新是否像血管紧张素II一样，在持续输注时会逐渐升高血压，以及这两种药物是否会改变动脉血压的昼夜变化。八只雌性Wistar大鼠静脉输注5%葡萄糖2天，然后以10微克·千克-1·分钟-1的剂量输注沙拉新4天，最后再输注葡萄糖2天。另外六只大鼠输注血管紧张素II（20纳克·千克-1·分钟-1）而非沙拉新。连续记录平均动脉压（MAP）。沙拉新和血管紧张素II在所有大鼠中均使MAP逐渐升高，沙拉新输注第4天时升高22.0 mmHg，血管紧张素II输注第4天时升高41.7 mmHg。两种药物还增加了血压的昼夜变化，MAP在夜间升高8.3 - 20.6 mmHg，在白天下降6.7 - 19.1 mmHg。沙拉新增加了动脉压的变异性，在早期实验中血管紧张素II也有此作用。我们得出结论，沙拉新具有与血管紧张素II相似的缓慢升压作用，但在时间上既不同于沙拉新的快速激动剂作用，也不同于血管紧张素II的急性血管收缩作用。沙拉新的这些作用可能会影响通过长时间输注该药物来评估血管紧张素II作用的实验结果的解读。
