Coker D D, Elias E G, Viravathana T, McCrea E, Hafiz M
Arch Dermatol. 1983 Jan;119(1):44-50.
Metastatic basal cell carcinoma is a rare, malignant neoplasm associated with poor survival. A 63-year-old woman had an extensive primary keratinizing basal cell carcinoma of the scalp, with metastases to the regional lymph nodes of the neck. Disease in the primary site and in the regional lymph nodes was controlled by surgery and irradiation. However, skeletal metastases that responded to therapy with three courses of cisplatin and bleomycin sulfate and then to ten courses of cyclophosphamide, methotrexate, and fluorouracil developed. Subsequent progressive metastases failed to respond to a combined cisplatin and cyclophosphamide regimen as well as to etoposide and doxorubicin hydrochloride used as single agents.
转移性基底细胞癌是一种罕见的恶性肿瘤，与生存率低相关。一名63岁女性患有广泛的头皮原发性角化性基底细胞癌，并转移至颈部区域淋巴结。原发部位和区域淋巴结的疾病通过手术和放疗得到控制。然而，出现了骨骼转移，对三疗程顺铂和硫酸博来霉素治疗有反应，随后对十疗程环磷酰胺、甲氨蝶呤和氟尿嘧啶治疗也有反应。随后进展性转移对顺铂和环磷酰胺联合方案以及作为单一药物使用的依托泊苷和盐酸多柔比星均无反应。
