Vives F, Gayoso M J, Osorio C, Mora F
Behav Brain Res. 1983 Apr;8(1):23-32. doi: 10.1016/0166-4328(83)90169-9.
Afferent projections to points of self-stimulation (SS) in the medial prefrontal cortex (MPC) of the rat were studied using the horseradish peroxidase (HRP) technique. Intracranial microinjections of HRP (30%) were delivered at the same stereotaxic points at which the electrodes eliciting SS were located. Retrogradely transported HRP labeled neurons in different thalamic, hypothalamic, mesencephalic and pontine areas. In the thalamus, labeled neurons were found in the dorsomedial, anteromedial, anteroventral, ventral, ventromedial, posteromedial, paratenial, parafascicular nuclei and n. reuniens. Labeled neurons in mesencephalic areas were found in the n. interpeduncularis, ventral tegmental area (AVT) and substantia nigra (SN). In the pons, labeled neurons were found in the locus coeruleus and in the periaqueductal gray. Other nuclei in which labeled neurons were also found were: lateral hypothalamus (LH), periventricular gray and zona incerta (ZI). Theoretically it is possible that all these afferent areas contribute to SS of MPC. This assumption is discussed and criticized in connection with previous literature on SS. It is suggested that only specific areas and their projections are good candidates for the neural mechanisms involved in the reward produced by electrical stimulation of the prefrontal cortex.
采用辣根过氧化物酶（HRP）技术研究了大鼠内侧前额叶皮质（MPC）中自我刺激（SS）点的传入投射。将HRP（30%）颅内微量注射到引发SS的电极所在的相同立体定位点。逆行运输的HRP标记了不同丘脑、下丘脑、中脑和脑桥区域的神经元。在丘脑中，在背内侧、前内侧、前腹侧、腹侧、腹内侧、后内侧、旁中央、束旁核和 reunien 核中发现了标记神经元。在中脑区域，在脚间核、腹侧被盖区（AVT）和黑质（SN）中发现了标记神经元。在脑桥中，在蓝斑和导水管周围灰质中发现了标记神经元。还发现标记神经元的其他核团有：外侧下丘脑（LH）、室周灰质和未定带（ZI）。理论上，所有这些传入区域都可能参与MPC的SS。结合之前关于SS的文献对这一假设进行了讨论和批评。有人提出，只有特定区域及其投射才是参与前额叶皮质电刺激产生奖励的神经机制的良好候选者。
