人口服三氟拉嗪的处置动力学。
Kinetics of oral trifluoperazine disposition in man.
作者信息
Midha K K, Korchinski E D, Verbeeck R K, Roscoe R M, Hawes E M, Cooper J K, McKay G
出版信息
Br J Clin Pharmacol. 1983 Mar;15(3):380-2. doi: 10.1111/j.1365-2125.1983.tb01515.x.
Abstract
The disposition of trifluoperazine (TFP) was studied in five healthy volunteers following oral administration of a 5 mg tablet. Using a very sensitive GC-MS technique plasma TFP concentrations were measured up until 24 h following drug ingestion. Peak plasma concentrations varied widely (range 0.53-3.09 ng ml-1) and were reached 2.8 +/- 0.5 h following ingestion of the TFP tablet. The apparent terminal elimination half-life of TFP was 12.5 +/- 1.4 h. The area under the plasma concentration-time curve differed widely between subjects (range: 5.9-17.6 ng ml-1 h) suggesting large individual differences in the extent of presystemic TFP elimination.
摘要
在五名健康志愿者口服5毫克三氟拉嗪（TFP）片剂后，对其处置情况进行了研究。采用非常灵敏的气相色谱-质谱联用（GC-MS）技术，在药物摄入后直至24小时测量血浆TFP浓度。血浆峰值浓度差异很大（范围为0.53 - 3.09纳克/毫升），在摄入TFP片剂后2.8±0.5小时达到。TFP的表观终末消除半衰期为12.5±1.4小时。受试者之间血浆浓度-时间曲线下面积差异很大（范围：5.9 - 17.6纳克/毫升·小时），表明TFP在体循环前消除程度存在很大个体差异。
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