Weerasinghe D Kavindi, Hodge Jason M, Pasco Julie A, Samarasinghe Rasika M, Azimi Manavi Behnaz, Williams Lana J
IMPACT-The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, VIC, Australia.
Barwon Health, Geelong, VIC, Australia.
Front Cell Dev Biol. 2023 May 25;11:1184550. doi: 10.3389/fcell.2023.1184550. eCollection 2023.
Antipsychotics are commonly used in treating psychiatric disorders. These medications primarily target dopamine the serotonin receptors, they have some affinity to adrenergic, histamine, glutamate and muscarinic receptors. There is clinical evidence that antipsychotic use decreases BMD and increases fracture risk, with dopamine, serotonin and adrenergic receptor-signalling becoming an increasing area of focus where the presence of these receptors in osteoclasts and osteoblasts have been demonstrated. Osteoclasts and osteoblasts are the most important cells in the bone remodelling and the bone regeneration process where the activity of these cells determine the bone resorption and formation process in order to maintain healthy bone. However, an imbalance in osteoclast and osteoblast activity can lead to decreased BMD and increased fracture risk, which is also believed to be exacerbated by antipsychotics use. Therefore, the aim of this review is to provide an overview of the mechanisms of action of first, second and third generation antipsychotics and the expression profiles of dopamine, serotonin and adrenergic receptors during osteoclastogenesis and osteoblastogenesis.
抗精神病药物常用于治疗精神疾病。这些药物主要作用于多巴胺和5-羟色胺受体，它们对肾上腺素能、组胺、谷氨酸和毒蕈碱受体也有一定亲和力。有临床证据表明，使用抗精神病药物会降低骨密度并增加骨折风险，多巴胺、5-羟色胺和肾上腺素能受体信号传导正成为一个日益受到关注的领域，破骨细胞和成骨细胞中已证实存在这些受体。破骨细胞和成骨细胞是骨重塑和骨再生过程中最重要的细胞，这些细胞的活性决定了骨吸收和形成过程，以维持骨骼健康。然而，破骨细胞和成骨细胞活性的失衡会导致骨密度降低和骨折风险增加，抗精神病药物的使用也被认为会加剧这种情况。因此，本综述的目的是概述第一代、第二代和第三代抗精神病药物的作用机制，以及破骨细胞生成和成骨细胞生成过程中多巴胺、5-羟色胺和肾上腺素能受体的表达情况。
