Uhari M, Reinilä A, Tarkka M
Br J Exp Pathol. 1983 Apr;64(2):191-7.
The possibility of preventing morphological changes in arterial walls in coarctation of the thoracic aorta with antihypertensive therapy was evaluated in an experimental study on dogs. Seven mongrel dogs weighing 2350-2980 g were operated upon at the age of 2 months. Antihypertensive therapy with a diuretic (hydrocholothiazide 25 mg/day), beta-blocker (propranolol and 80 mg/day) and vasodilatator (prazosin ad 40 mg/day) was started 1 month after the experimental coarctation was produced in the animals. Blood pressure decreased significantly, although not to the level of the control group. Seven months after the coarctation a perfusion fixation was done. Morphometrical light microscopic analysis was performed on the coronary and cerebral arteries. The histochemical findings in the aorta were analysed qualitatively, as was the amount of lipid in the coronary and the middle cerebral arteries. Electron microscopic studies were performed on the coronary artery. The findings were compared to the control and coarctated (non-treated) groups studied earlier (Uhari et al., 1982). Active antihypertensive therapy prevented all the major morphological changes previously reported to occur in coarctation. We suggest that active antihypertensive therapy started immediately after the diagnosis of coarctation might improve the prognosis of the patients with aortic coarctation by preventing morphological changes in the great arteries.
在一项针对犬类的实验研究中，评估了通过抗高血压疗法预防胸主动脉缩窄时动脉壁形态学变化的可能性。7只体重在2350 - 2980克的杂种犬在2个月大时接受了手术。在动物产生实验性缩窄后1个月，开始使用利尿剂（氢氯噻嗪25毫克/天）、β受体阻滞剂（普萘洛尔80毫克/天）和血管扩张剂（哌唑嗪达40毫克/天）进行抗高血压治疗。血压显著下降，尽管未降至对照组水平。缩窄7个月后进行灌注固定。对冠状动脉和脑动脉进行形态计量学光镜分析。对主动脉的组织化学结果进行定性分析，同时分析冠状动脉和大脑中动脉中的脂质含量。对冠状动脉进行电子显微镜研究。将结果与之前研究的对照组和缩窄（未治疗）组进行比较（乌哈里等人，1982年）。积极的抗高血压治疗预防了先前报道的在缩窄中出现的所有主要形态学变化。我们建议，在诊断出缩窄后立即开始积极的抗高血压治疗，可能通过预防大动脉的形态学变化来改善主动脉缩窄患者的预后。
