Vakakis N, Redgrave T G, Small D M, Castelli W P
Biochim Biophys Acta. 1983 May 16;751(3):280-5. doi: 10.1016/0005-2760(83)90285-0.
The red blood cells and the low-density lipoproteins in hypertriglyceridemia have a lower ratio of unesterified cholesterol to phospholipid than normal. The low-density lipoproteins are also smaller and more dense in hypertriglyceridemia, and contain only 45% of the normal unesterified cholesterol mass. The phase behavior of the lipids shows that normal red cells and low-density lipoproteins are close to saturation with cholesterol, whereas in hypertriglyceridemia less cholesterol is present. Because newly secreted triacylglycerol-rich lipoproteins are poor in cholesterol, their excess production and transport in hypertriglyceridemia may prevent maintenance of the normal cholesterol content of blood cells and low-density lipoproteins. Partitioning of cholesterol into triacylglycerol-rich lipoproteins is able to account for significant fluxes of unesterified cholesterol in the plasma compartment.
高甘油三酯血症患者的红细胞和低密度脂蛋白中，未酯化胆固醇与磷脂的比例低于正常水平。高甘油三酯血症患者的低密度脂蛋白也更小且密度更高，其未酯化胆固醇质量仅为正常水平的45%。脂质的相行为表明，正常红细胞和低密度脂蛋白接近胆固醇饱和状态，而在高甘油三酯血症中，胆固醇含量较低。由于新分泌的富含三酰甘油的脂蛋白胆固醇含量低，其在高甘油三酯血症中的过量产生和转运可能会妨碍维持血细胞和低密度脂蛋白的正常胆固醇含量。胆固醇向富含三酰甘油的脂蛋白的分配能够解释血浆中未酯化胆固醇的大量流动。
