Cabanac M, Dib B
Brain Res. 1983 Mar 28;264(1):79-87. doi: 10.1016/0006-8993(83)91122-8.
Rats with hypothalamic thermodes had their hypothalamus cooled or warmed for short sessions. In a first series of experiments, rats could bar-press to obtain fanning with cool air. Cooling the hypothalamus did not suppress or inhibit this behaviour although rectal temperature was markedly increased. In a second series of experiments, bar-pressing would warm the water flowing in the thermode. The rats thus self suppressed the cooling of their hypothalamus. This behaviour was absent at 10 degrees C ambient temperature, and increased with increasing ambient temperature up to 35 degrees C. The result of this behaviour was a small hyperthermia in warm and hot environment compared to control when the rats could not self-suppress the cooling of hypothalamus. The results of both experiments suggest that no conscious direct sensation is aroused by hypothalamic cooling. Hypothalamic heating increased the rat's bar-pressing for cool air and decreased the rat's rectal temperature. When pressure on the lever would suppress a warm hypothalamic stimulus rats self-cooled their hypothalamus, especially in warm environments. Such behaviour resulted in an increased somatic hyperthermia due to the warm environment and hypothalamic cooling. These results are compatible with the hypothesis of a direct conscious sensation from a warm hypothalamus.
对带有下丘脑温度调节装置的大鼠进行短时间的下丘脑冷却或加热处理。在第一组实验中，大鼠可以通过按压杠杆来获得冷空气吹拂。尽管直肠温度显著升高，但冷却下丘脑并未抑制或阻止这种行为。在第二组实验中，按压杠杆会使温度调节装置中的水流变暖。因此，大鼠会自我抑制下丘脑的冷却。在环境温度为10摄氏度时，这种行为并不存在，且随着环境温度升高至35摄氏度，该行为会增加。与大鼠无法自我抑制下丘脑冷却时的对照组相比，在温暖和炎热环境中，这种行为的结果是出现轻微的体温过高。这两组实验结果均表明，下丘脑冷却不会引发有意识的直接感觉。下丘脑加热增加了大鼠对冷空气的按压杠杆行为，并降低了大鼠的直肠温度。当按压杠杆会抑制下丘脑的温热刺激时，大鼠会自我冷却下丘脑，尤其是在温暖环境中。由于温暖环境和下丘脑冷却，这种行为导致体温过高加剧。这些结果与来自温热下丘脑的直接有意识感觉的假设相符。
