Saxena A, Tandon J P
Cancer Lett. 1983 May;19(1):73-6. doi: 10.1016/0304-3835(83)90138-6.
Some new di-n-butyltin and tin(IV) complexes of the type Bu2SnL, Bu2SnL2 and SnL2 (where L = anions of Schiff bases derived from S-substituted dithiocarbazates and fluoro-aniline) have been prepared and screened for their antitumor activity in P 388 Lymphocyte Leukaemia system. These complexes do not show any toxicity at low dose levels and display T/C values in the range 94-124. Di-n-butyltin complex derived from salicylaldehyde-S-methyl dithiocarbazate has been found to be the most active in this series.
已制备出一些新型的二正丁基锡和四价锡配合物，其类型为Bu2SnL、Bu2SnL2和SnL2（其中L = 由S-取代二硫代氨基甲酸盐和氟代苯胺衍生的席夫碱阴离子），并在P 388淋巴细胞白血病系统中对它们的抗肿瘤活性进行了筛选。这些配合物在低剂量水平下未显示出任何毒性，其T/C值在94 - 124范围内。已发现由水杨醛-S-甲基二硫代氨基甲酸盐衍生的二正丁基锡配合物在该系列中活性最高。
