Dorr R T, Alberts D S
Cancer Treat Rep. 1983 May;67(5):499-501.
Doxorubicin (DOX)-induced skin ulceration in rats and pigs has been reported to be reduced when treated with topical DMSO and/or vitamin E. In the present study using a mouse model, neither intradermal nor topical DMSO with or without vitamin E, administered up to 7 days, reduced intradermal DOX-induced skin ulceration. Intradermal DMSO with or without vitamin E caused skin ulceration and significantly increased DOX-induced ulcerations. Topical DMSO-containing solutions were not toxic to mouse skin. To test for a systemic effect of topical DMSO, two groups of mice received an additional 0.05-mg intradermal injection of DOX above a DMSO-treated lesion. There was no apparent effect of topical DMSO with or without vitamin E on this proximal but untreated DOX lesion. The results suggest either a major difference in DOX ulceration characteristics between rats and pigs on the one hand and mice on the other hand or a lack of significant efficacy for DMSO and vitamin E as DOX extravasation antidotes.
据报道，用局部二甲基亚砜（DMSO）和/或维生素E治疗时，阿霉素（DOX）诱导的大鼠和猪皮肤溃疡会减轻。在本研究使用的小鼠模型中，皮内注射或局部应用含或不含维生素E的DMSO，给药长达7天，均未减轻皮内注射DOX诱导的皮肤溃疡。含或不含维生素E的皮内DMSO会导致皮肤溃疡，并显著增加DOX诱导的溃疡。含DMSO的局部溶液对小鼠皮肤无毒。为了测试局部DMSO的全身作用，两组小鼠在经DMSO处理的损伤上方额外皮内注射0.05 mg DOX。含或不含维生素E的局部DMSO对这个近端但未处理的DOX损伤没有明显影响。结果表明，一方面大鼠和猪与另一方面小鼠之间在DOX溃疡特征上存在重大差异，或者DMSO和维生素E作为DOX外渗解毒剂缺乏显著疗效。
