Takeuchi Y, Sano Y
Cell Tissue Res. 1983;231(1):17-28. doi: 10.1007/BF00215770.
By the use of a modified peroxidase-antiperoxidase immunohistochemical method, the distribution of serotonin-containing nerve fibers was studied in the inferior olivary complex of the rat, cat and monkey. The entire inferior olivary complex of all three species contained serotonin fibers, and species-related differences in the distribution of serotonin fibers were observed. In the rat, the overall density of serotonin fibers was sparser than that in the other two species; the highest concentration of varicose serotonergic fibers was noted in the lateral portion of the dorsal accessory olive. In the cat, the densest distribution of serotonin fibers occurred in the caudal portion of the medial accessory olive, the dorsomedial cell column and the lateral portion of the dorsal accessory olive, where intervaricose segments of serotonin-immunoreactive fibers were not so distinct. In the monkey, the caudal medial accessory olive, the lateral portion of the dorsal accessory olive and the dorsal as well as the lateral lamella of the principal olive showed a maximum density of serotonin fibers. Apart from the influence of afferent serotonergic projections to the cerebellum, serotonergic neurons of the brainstem are considered to affect Purkinje cells via neurons of the inferior olivary complex projecting to the cerebellum particularly in the cat and monkey.
运用改良的过氧化物酶-抗过氧化物酶免疫组织化学方法，对大鼠、猫和猴的下橄榄复合体中含5-羟色胺的神经纤维分布进行了研究。所有这三个物种的整个下橄榄复合体均含有5-羟色胺纤维，并且观察到了5-羟色胺纤维分布上的种属差异。在大鼠中，5-羟色胺纤维的总体密度比其他两个物种中的稀疏；曲张的5-羟色胺能纤维的最高浓度见于背侧副橄榄核的外侧部分。在猫中，5-羟色胺纤维分布最密集的部位是内侧副橄榄核的尾部、背内侧细胞柱以及背侧副橄榄核的外侧部分，其中5-羟色胺免疫反应性纤维的曲张间节段不那么明显。在猴中，内侧副橄榄核的尾部、背侧副橄榄核的外侧部分以及主橄榄核的背侧和外侧薄片显示出5-羟色胺纤维的最大密度。除了传入的5-羟色胺能投射对小脑的影响外，脑干的5-羟色胺能神经元被认为通过投射至小脑的下橄榄复合体神经元影响浦肯野细胞，这在猫和猴中尤为明显。
