偏头痛中白细胞释放组胺的情况。

Histamine release from leucocytes in migraine.

作者信息

Selmaj K

出版信息

Cephalalgia. 1983 Mar;3(1):37-40. doi: 10.1046/j.1468-2982.1983.0301037.x.

DOI:10.1046/j.1468-2982.1983.0301037.x

Abstract

The spontaneous histamine release (SHR) from leucocytes in migraine patients during symptom-free periods has been investigated, and also the influence of migraine sufferer serum on histamine release (HR) from blood donor leucocytes. The leucocytes were isolated according to the Day method and histamine assay was made by the Shore spectrofluorometric method modified by Bergendorff and Uväs (1). SHR in the 17 female migraine patients was significantly higher (39.7% +/- 13.1%) than in 8 controls (25.4% +/- 4.2%). Migraine serum increased HR from blood donor leucocytes by 14.6% +/- 20.2% compared with the SHR of these cells.

摘要

研究了偏头痛患者在无症状期白细胞的组胺自发释放（SHR），以及偏头痛患者血清对献血者白细胞组胺释放（HR）的影响。白细胞按照戴氏方法分离，组胺测定采用经贝根多夫和乌瓦斯改进的肖尔荧光分光光度法（1）。17名女性偏头痛患者的SHR（39.7%±13.1%）显著高于8名对照者（25.4%±4.2%）。与这些细胞的SHR相比，偏头痛血清使献血者白细胞的HR增加了14.6%±20.2%。