Henriksen O, Amtorp O, Faris I, Agerskov K
Circ Res. 1983 May;52(5):534-42. doi: 10.1161/01.res.52.5.534.
The study was performed in order to determine whether a local sympathetic venoarteriolar "reflex" is present in the dog hindleg. Femoral artery blood flow was measured by an electromagnetic flowmeter probe, and blood flow in the thigh muscle and subcutaneous tissue distally in the paw was measured by the local 133Xe washout technique. Twenty experiments were carried out in seven dogs unilaterally sympathectomized 2-4 weeks previously. Resting vascular tone did not differ in the sympathectomized and nonsympathectomized legs. In the control leg, venous pressure elevation caused a decrease in femoral blood flow of 49% corresponding to an increase in vascular resistance of 58%. In muscle and subcutaneous tissue vascular resistance increased by 81% and 35%, respectively. In the denervated leg, venous stasis caused no change in total vascular resistance. In muscle the vascular resistance increased by only 24%. In subcutaneous tissue, vascular resistance decreased by 12%. The effect of acute lumbar sympathectomy was studied in another group of seven dogs. Operation caused an immediate decrease in vascular resistance of 40%. The increase in vascular resistance during venous stasis in the total leg, as well as in muscle and subcutaneous tissue, was not affected. However, acute lumbar sympathectomy combined with injection of phenoxybenzamine into the femoral artery almost abolished the vasoconstriction induced by venous stasis. In muscle, the increase in vascular resistance was still present, but considerably attenuated. In subcutaneous tissue, the normal response was completely blocked. Finally, local suction induced vasoconstriction in an adjoining area not subjected to changes in vascular transmural pressure, an effect that could be blocked by local neural blockade at the site of suction. The results strongly suggest that a local sympathetic veno-arteriolar (axon) "reflex" is present in muscle and subcutaneous tissue in the dog hindleg.
进行这项研究是为了确定狗后肢是否存在局部交感神经静脉小动脉“反射”。用电磁流量计探头测量股动脉血流量，并用局部¹³³Xe洗脱技术测量爪部远端大腿肌肉和皮下组织的血流量。在7只2 - 4周前进行单侧交感神经切除术的狗身上进行了20次实验。交感神经切除的腿和未切除的腿在静息血管张力方面没有差异。在对照腿中，静脉压升高导致股血流量减少49%，相应的血管阻力增加58%。肌肉和皮下组织的血管阻力分别增加了81%和35%。在去神经的腿中，静脉淤滞并未引起总血管阻力的变化。肌肉中的血管阻力仅增加了24%。皮下组织的血管阻力下降了12%。在另一组7只狗身上研究了急性腰交感神经切除术的效果。手术导致血管阻力立即下降40%。静脉淤滞期间全腿以及肌肉和皮下组织中血管阻力的增加不受影响。然而，急性腰交感神经切除术联合股动脉注射酚苄明几乎消除了静脉淤滞引起的血管收缩。在肌肉中，血管阻力的增加仍然存在，但明显减弱。在皮下组织中，正常反应完全被阻断。最后，局部抽吸在未受血管跨壁压变化影响的相邻区域引起血管收缩，这种效应可被抽吸部位的局部神经阻滞所阻断。结果强烈表明狗后肢的肌肉和皮下组织中存在局部交感神经静脉小动脉（轴突）“反射”。
