夜猴（Aotus）V核型（2n = 46）和VI核型（2n = 49、50）的比较基因图谱。

Comparative gene mapping of the owl monkey, Aotus, with karyotypes V (2n = 46) and VI (2n = 49, 50).

作者信息

Ma N S

出版信息

Cytogenet Cell Genet. 1983;35(2):117-23. doi: 10.1159/000131852.

Abstract

Biochemical analysis of cytogenetically defined rodent--owl monkey hybrid cell lines segregating owl monkey chromosomes allowed the assignment of 14 structural gene markers to seven owl monkey karyotype V (K-V, 2n = 46) chromosomes. Comparative study of assigned gene loci to chromosomes of owl monkey karyotype V (K-V, 2n = 46) and karyotype VI (K-VI, 2n = 49/50) provides the first evidence supporting some of the previously proposed mechanics of chromosomal rearrangements responsible for the great karyotypic diversity in owl monkeys. In addition, chromosome homologies deduced from gene loci of Aotus and other primates are compared here to determine the conservation or modification of chromosome morphology in the course of primate evolution. The data demonstrate the usefulness of gene mapping as an alternative to banding patterns for obtaining evidence on chromosome evolution.

摘要

对细胞遗传学定义的啮齿动物 - 夜猴杂交细胞系进行生化分析，这些细胞系正在分离夜猴染色体，从而将14个结构基因标记定位到7条夜猴核型V（K-V，2n = 46）染色体上。对夜猴核型V（K-V，2n = 46）和核型VI（K-VI，2n = 49/50）染色体上指定基因座的比较研究，首次提供了证据，支持了一些先前提出的导致夜猴巨大核型多样性的染色体重排机制。此外，在此比较从夜猴和其他灵长类动物的基因座推导的染色体同源性，以确定在灵长类动物进化过程中染色体形态的保守性或变化。数据表明基因定位作为一种替代带型模式获取染色体进化证据的方法是有用的。