Thüroff J W, Schmidt R A, Bazeed M A, Tanagho E A
Eur Urol. 1983;9(2):102-8. doi: 10.1159/000474058.
To investigate the feasibility of chronic stimulation of the sacral nerves for control of sphincter and bladder function, we implanted bipolar electrodes in 10 dogs. These electrodes, of conventional cuff (4 dogs), as well as innovative spiral designs (6 dogs) were placed around the S2 roots of the 10 dogs and in 3 of them around the S1 root additionally. The electrodes were connected to subcutaneous radiofrequency receivers for external activation. Microsurgical techniques were employed to perform dorsal rhizotomy and ganglionectomy. 5 dogs, 3 kept as long as 8 months, were chronically stimulated to a cumulated time of 100-150 h each. Functional and histological results reveal that sacral root nerves can be stimulated safely on a chronic basis for effective control of the lower urinary tract.
为研究长期刺激骶神经以控制括约肌和膀胱功能的可行性，我们在10只狗身上植入了双极电极。这些电极，包括传统袖套式（4只狗）以及创新的螺旋式设计（6只狗），被放置在10只狗的S2神经根周围，其中3只狗还在S1神经根周围额外放置了电极。电极连接到皮下射频接收器以便进行外部激活。采用显微外科技术进行背根切断术和神经节切除术。对5只狗进行了长期刺激，其中3只长达8个月，每只狗的累积刺激时间为100 - 150小时。功能和组织学结果表明，骶神经根神经可以在长期基础上安全地进行刺激，以有效控制下尿路。
