运动诱导的大鼠比目鱼肌神经形态学变化。

Activity-induced morphologic changes in rat soleus nerve.

作者信息

Roy R R, Gilliam T B, Taylor J F, Heusner W W

出版信息

Exp Neurol. 1983 Jun;80(3):622-32. doi: 10.1016/0014-4886(83)90312-6.

Abstract

The effects of 8 to 12 weeks of intense running or swimming on the morphology of the soleus nerve of the adult male albino rat were investigated. Nerve fiber diameter and number, axon diameter, and myelin area were determined. Mean fiber diameter (5.50 +/- 0.47) of the trained rats was smaller (P less than 0.05) than for sedentary control rats (6.19 +/- 0.27). The decrease in fiber size in the trained rats appeared to be reflected by a combination of smaller (P greater than 0.05) mean axon diameter and myelin area. Total fiber number was not different in the control (means = 113 +/- 6) and trained (means = 108 +/- 4) rats. These results provide further evidence that a chronic, intense but physiologic exercise can impose a functional demand on peripheral nerves that can alter morphologic features that are closely related to conduction velocity and commonly are associated with neuronal cell size.

摘要

研究了8至12周的高强度跑步或游泳对成年雄性白化大鼠比目鱼肌神经形态的影响。测定了神经纤维直径和数量、轴突直径以及髓鞘面积。训练组大鼠的平均纤维直径（5.50±0.47）比久坐不动的对照组大鼠（6.19±0.27）小（P<0.05）。训练组大鼠纤维大小的减小似乎是由平均轴突直径和髓鞘面积较小（P>0.05）共同导致的。对照组（均值=113±6）和训练组（均值=108±4）大鼠的纤维总数没有差异。这些结果进一步证明，长期、高强度但生理性的运动可对外周神经施加功能性需求，从而改变与传导速度密切相关且通常与神经元细胞大小相关的形态学特征。