Sterman A B
Exp Neurol. 1983 Jun;80(3):726-31. doi: 10.1016/0014-4886(83)90321-7.
The prototype environmental neurotoxin, 2,5-hexanedione (2,5-HD), induces changes in somata of sensory ganglia that are morphologically similar to chromatolysis: this study assessed the functional significance of neuronal alterations. Experimental rats were exposed 6 weeks to 2,5-HD, and after 1 week without treatment were then subjected to experimental crush of the sciatic nerve (paired controls were unintoxicated). Nerve regeneration was assayed by the pinch test 4 to 13 days after crush. These preliminary results did not show an accelerated rate of axonal outgrowth; however, there was a small but significant (P less than 0.05) decrease in the initial delay.
原型环境神经毒素2,5 -己二酮（2,5 - HD）可引起感觉神经节神经元胞体发生形态学上类似于染色质溶解的变化：本研究评估了神经元改变的功能意义。将实验大鼠暴露于2,5 - HD 6周，在未经处理1周后，对坐骨神经进行实验性挤压（配对对照组未中毒）。在挤压后4至13天通过捏压试验测定神经再生情况。这些初步结果并未显示轴突生长速率加快；然而，初始延迟有轻微但显著的降低（P小于0.05）。
